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Year Number of Results
1976 2
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1984 37
1985 34
1986 51
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1988 71
1989 65
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1998 127
1999 122
2000 106
2001 123
2002 137
2003 154
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2005 178
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2008 174
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2013 239
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2023 238
2024 77

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5,897 results

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Page 1
Fluoroquinolone-Gyrase-DNA Cleaved Complexes.
Luan G, Drlica K. Luan G, et al. Methods Mol Biol. 2018;1703:269-281. doi: 10.1007/978-1-4939-7459-7_19. Methods Mol Biol. 2018. PMID: 29177748
The quinolones are potent antibacterials that act by forming complexes with DNA and either gyrase or topoisomerase IV. These ternary complexes, called cleaved complexes because the DNA moiety is broken, block replication, transcription, and bacterial growth. …
The quinolones are potent antibacterials that act by forming complexes with DNA and either gyrase or topoisomerase IV. These t …
The regulation of DNA supercoiling across evolution.
Duprey A, Groisman EA. Duprey A, et al. Protein Sci. 2021 Oct;30(10):2042-2056. doi: 10.1002/pro.4171. Epub 2021 Aug 23. Protein Sci. 2021. PMID: 34398513 Free PMC article. Review.
As a physical property, DNA supercoiling alters the double helix structure by under- or over-winding it. ...Nucleoid-associated proteins, metabolites, and physicochemical factors influence DNA supercoiling by acting on the DNA itself or by impacting the activ …
As a physical property, DNA supercoiling alters the double helix structure by under- or over-winding it. ...Nucleoid-associated prote …
Bacillus subtilis deoxyribonucleic acid gyrase.
Sugino A, Bott KF. Sugino A, et al. J Bacteriol. 1980 Mar;141(3):1331-9. doi: 10.1128/jb.141.3.1331-1339.1980. J Bacteriol. 1980. PMID: 6245067 Free PMC article.
Bacillus subtilis 168 was shown to contain a deoxyribonucleic acid (DNA) gyrase activity which closely resembled those of the enzymes isolated from Escherichia coli and Micrococcus luteus in its enzymatic requirements, substrate specificity, and sensit …
Bacillus subtilis 168 was shown to contain a deoxyribonucleic acid (DNA) gyrase activity which closely resembled …
New nalidixic acid resistance mutations related to deoxyribonucleic acid gyrase activity.
Yamagishi J, Furutani Y, Inoue S, Ohue T, Nakamura S, Shimizu M. Yamagishi J, et al. J Bacteriol. 1981 Nov;148(2):450-8. doi: 10.1128/jb.148.2.450-458.1981. J Bacteriol. 1981. PMID: 6271730 Free PMC article.
In Escherichia coli K-12 mutants which had a new nalidixic acid resistance mutation at about 82 min on the chromosome map, cell growth was resistant to or hypersusceptible to nalidixic acid, oxolinic acid, piromidic acid, pipemidic acid, and nov …
In Escherichia coli K-12 mutants which had a new nalidixic acid resistance mutation at about 82 min on the chromosome map, cell growt …
What makes a type IIA topoisomerase a gyrase or a Topo IV?
Hirsch J, Klostermeier D. Hirsch J, et al. Nucleic Acids Res. 2021 Jun 21;49(11):6027-6042. doi: 10.1093/nar/gkab270. Nucleic Acids Res. 2021. PMID: 33905522 Free PMC article. Review.
Type IIA topoisomerases catalyze a variety of different reactions: eukaryotic topoisomerase II relaxes DNA in an ATP-dependent reaction, whereas the bacterial representatives gyrase and topoisomerase IV (Topo IV) preferentially introduce negative supercoils into …
Type IIA topoisomerases catalyze a variety of different reactions: eukaryotic topoisomerase II relaxes DNA in an ATP-dependent reacti …
Investigating the mechanism of binding of nalidixic acid with deoxyribonucleic acid and serum albumin: a biophysical and molecular docking approaches.
Siddiqui S, Mujeeb A, Ameen F, Ishqi HM, Rehman SU, Tabish M. Siddiqui S, et al. J Biomol Struct Dyn. 2021 Feb;39(2):570-585. doi: 10.1080/07391102.2020.1711808. Epub 2020 Jan 20. J Biomol Struct Dyn. 2021. PMID: 31910794
Nalidixic acid is a bacterial DNA gyrase inhibitor and the first member of the synthetic quinolone antibiotics. ...UV-visible absorption and fluorescence spectroscopic experiments confirmed the formation of a complex between nalidixic acid with ct-D …
Nalidixic acid is a bacterial DNA gyrase inhibitor and the first member of the synthetic quinolone antibiotics. ...UV-v …
DNA mimicry by proteins.
Dryden DT, Tock MR. Dryden DT, et al. Biochem Soc Trans. 2006 Apr;34(Pt 2):317-9. doi: 10.1042/BST20060317. Biochem Soc Trans. 2006. PMID: 16545103 Review.
These mimics target a range of proteins and enzymes such as DNA restriction enzymes, DNA repair enzymes, DNA gyrase and nucleosomal and nucleoid-associated proteins. The unusual properties of these protein DNA mimics may provide a foundation for …
These mimics target a range of proteins and enzymes such as DNA restriction enzymes, DNA repair enzymes, DNA gyrase …
DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion.
Bax BD, Murshudov G, Maxwell A, Germe T. Bax BD, et al. J Mol Biol. 2019 Aug 23;431(18):3427-3449. doi: 10.1016/j.jmb.2019.07.008. Epub 2019 Jul 10. J Mol Biol. 2019. PMID: 31301408 Free PMC article. Review.
Type II topoisomerases regulate DNA topology by making a double-stranded break in one DNA duplex, transporting another DNA segment through this break and then resealing it. ...To study the mode of action of such compounds, 21 crystal structures of a "gyras …
Type II topoisomerases regulate DNA topology by making a double-stranded break in one DNA duplex, transporting another DNA …
Why Two? On the Role of (A-)Symmetry in Negative Supercoiling of DNA by Gyrase.
Klostermeier D. Klostermeier D. Int J Mol Sci. 2018 May 16;19(5):1489. doi: 10.3390/ijms19051489. Int J Mol Sci. 2018. PMID: 29772727 Free PMC article. Review.
Gyrase is a type IIA topoisomerase that catalyzes negative supercoiling of DNA. ...The GyrA subunits contain two C-terminal domains (CTDs) for DNA binding and wrapping to stabilize the positive DNA node, and two catalytic tyrosines for DNA cleav …
Gyrase is a type IIA topoisomerase that catalyzes negative supercoiling of DNA. ...The GyrA subunits contain two C-terminal do …
Single DNA/protein studies with magnetic traps.
Meglio A, Praly E, Ding F, Allemand JF, Bensimon D, Croquette V. Meglio A, et al. Curr Opin Struct Biol. 2009 Oct;19(5):615-22. doi: 10.1016/j.sbi.2009.08.005. Epub 2009 Sep 23. Curr Opin Struct Biol. 2009. PMID: 19783425 Review.
They have been used with great success to investigate the interaction of stretched and supercoiled DNA and DNA fibers (e.g. chromatin) with a great variety of enzymes. In this small review we will address their recent use in the study of topoisomerases, gyrase …
They have been used with great success to investigate the interaction of stretched and supercoiled DNA and DNA fibers (e.g. ch …
5,897 results